| Titre : | Feeding mice with diet made up with mercury-contaminated fish flesh from French Guiana : A model for the environmental poisoning of the Wayana Amerindians |
| Auteurs : | J.P. Bourdineaud ; D. Brèthes ; P. Gonzalez ; [et al.] |
| Type de document : | article scientifique |
| Editeur : | Amsterdam : Elsevier, 2008 |
| Format : | S21 |
| Note générale : | in : Comparative Biochemistry and Physiology, Part A 151 (2008) |
| Langues: | Anglais |
| Catégories : |
[Ecoplanète] 1100 - HYGIENE - SANTE - MEDECINE > PHYSIOLOGIE > METABOLISME > REGIME ALIMENTAIRE [Ecoplanète] 1700 - SCIENCES > 1705 - ELEMENTS CHIMIQUES > MERCURE [Ecoplanète] 1800 - DIVERS > 1803 - MOTS OUTILS > RETOUR D'EXPERIENCE |
| Résumé : | In French Guiana, clandestine gold mining is responsible of the mercury amplification all along the food web. In 2005, 84% ofWayanas Amerindians living in the uppermarshes of the Maroni river presented a hair mercury concentration exceeding the limit set up by the World Health Organization (10 μg Hg/g).We choose the rodent model (mouse) to mimic as closely as possible the Wayanas' contamination mode. Therefore, lyophilized fish fleshwas incorporated into the preparation of mice alimentary pellets. This flesh was originating from fish contaminated by mercury in their natural habitat and caught in French Guiana. More precisely, the Hoplias aimara species was chosen because these fish are highly contaminated bymethylmercury (4 to 12 μgMeHg/g dw), and because this single species represents 27% of the Wayanas' dietary mercury intake and 10.7% of the total flesh consumed. A fish fleshcontaining diet was made up from a basic vegetal diet. This diet incorporated 0.1% lyophilized H. aimara flesh, yielding mercury concentrations of 5 ng MeHg per g of food pellets. After 3, 7 and 19 months of feeding with such a regimen, the effects of fish flesh mercury as compared to the control diet were assessed through tissue mercury content analysis, gene expression quantification,mitochondrial respiration assays, chimiokine and neurotransmitters analysis. Behavior was challenged after 2, 6, 12 and 19 months. Results are showing a dramatic impact of mercury at a contamination pressure of 1 ng Hg/day/g body weight beginning as soon as 1 month of exposure. (résumé d'auteur) |
